Denis Noble
(1936-)
Denis Noble is a British physiologist and biologist who was at the University of Oxford from 1984 to 2004 and was appointed professor emeritus and co-director of computational physiology.
Noble's research focuses on using computer models of biological organs and organ systems to interpret function from the molecular level to the whole organism. Together with international collaborators, his team used supercomputers to create the first virtual organ, the virtual heart.
Noble argues that from research in epigenetics, acquired characteristics can be inherited and in contrast to the
Modern Synthesis, genetic change is "far from random" and not always gradual. He has also claimed that the central dogma of molecular biology has been broken as an "embodiment of the
Weismann Barrier", and a new synthesis will integrate research from physiology with evolutionary biology.
Noble rejects natural selection as the primary mechanism of evolution, contrary to the longstanding consensus of evolutionary biologists, and with
James Shapiro in 2014, Noble established
The Third Way of Evolution (TWE) project which rejects natural selection as the primary cause of evolution and predicts that the entire framework of the modern synthesis of evolution will be replaced. The Third Way of Evolution aims to replace the Modern Synthesis and a divine origin of life.
Noble is also working with Harvard geneticist
George Church and advertising strategist Perry Marshall, offering an incentive prize ten times the size of the Nobel – believed to be the largest single award ever in basic science – to the person or team solving the largest mystery in history: how genetic code inside cells got there, and how cells intentionally self-organize, communicate, then purposely adapt. This $10 million challenge, the Evolution 2.0 Prize can be found at
herox.com/evolution2.0.
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