See cosmic creation process.

When a single neuron fires, the active potential rapidly changes the concentration of sodium (Na+) ions inside the cell and potassium (K+) ions outside the cell.

Within milliseconds, thousands of sodium-potassium ion transporters in the thin lipid bilayer of the cell wall must move billions of those ions, two or three at a time between inside and outside the cell wall, to get the neuron ready to fire again.

All the individual ions, atoms, and molecules in the cell are moving rapidly in random directions. The indeterministic motions of the ions randomly move some near the pump opening, where quantum collaborative forces can capture them in a lock-and-key structure. The idea that the physical/chemical base level contains enough information in the motion of its atoms and molecules to cause and explain the operations of the higher levels of life and mind is simply absurd.

The emergent biology of a sodium-potassium pump exerts downward causation on the ions, powered by ATP energy carriers (feeding on negative entropy).

The sodium-potassium pump in our neurons is as close to a Maxwell’s Demon as anything we are ever likely to see.